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July 27, 2017

Transgenic Rats Definition, Review and Creation

How Can Transgenic Rats be Helpful in Medical Research?

Rats are among the animals that have been associated to humans in many of their evolution properties. Due to their closeness to the human beings, they have always been in focus of scientific research and study. Most of the experiments are initially conducted on the rats, so as to find their possible affects on humans. The medical researchers deduce the affect of a particular medicine or treatment on human beings by checking out the results of the study that was conducted on rats. So, simply stating, the rats are used as models for deriving different products that can be useful for the health of a person.

There are different types of rates among which the transgenic rats are quite popular in the world of medical. Their properties are quite different compared to the normal wild rats, and particularity lies in the insertion of a foreign DNA in their genome. So, basically as the name depicts, the genome of this rat is modified deliberately by adding the genes of non-rat specie, so as to make it transgenic. This non-rat specie can be any organism including a human being, a plant or an aquarium. The alteration of the genome allows the amendment in the inherited characteristics of the rat, and hence different experiments can be carried out to read the affects on different organism. These rats look just like the other non-transgenic rats, but after mutation, their children also inherit the transgenic characteristics.

Transgenic Rat

Process of Transgenic Rat Creation
Creating Transgenic Rat is a complex process, and can be carried out by a person who has complete knowledge of the molecular biology. Following are the major steps involved in the creation of a transgenic rat;

  • 1. Selection of the genes by scientists
  • 2. Isolation of the gene
  • 3. Generation of gene copies
  • 4. Giving hormonal injections to female rat, and keeping her with a male inseminator for hyper-ovulation.
  • 5. Suctioning of the fertile rat eggs after killing her.
  • 6. Examination of the eggs
  • 7. Injecting hormone genes to another female rat for enforcing reproduction process
  • 8. Destruction of non-positive embryos and implantation of the positive embryos into the substitute female rate.
  • 9. The child rats possessing transgenic genome properties are kept with each other to ensure that the reproduction process doesn’t stop.
  • 10. The child rats with non-transgenic properties are destroyed.

Because of the transgenic rats, the process of medical research and drug development that can be beneficial for human health has become much easier and valuable. However, the results might not always be exactly same in case of humans.
About Author
Sophia Alexander is a chief editor since early 2007, and she currently works for Pets and their care. She is expert in writing about Transgenic mice and Homologous recombination.

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